MCI-9042, the New Selective Antagonist of Serotonergic (5-HT2A) Receptors
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چکیده
منابع مشابه
Role of 5-HT2A/C receptors in serotonergic modulation of respiratory motor output during tadpole development.
We tested the hypothesis that 5-HT(2A/C) receptors contribute to the modulation of respiratory motor output elicited by serotonin bath-application in the in vitro brainstem preparation from bullfrog tadpoles. Preparations were superfused with (1) a selective 5-HT(2A/C) receptor agonist (DOI, 0.5-25 microM) or (2) 5-HT in presence of a non-selective 5-HT(2A/C) receptor antagonist (methysergide m...
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Serotonin [5-hydroxytryptamine (5-HT)] and 5-HT receptors are involved in sleep and in waking functions such as cognition and mood. Animal and human studies support a particular role for the 5-HT(2A) receptor in sleep, which has led to renewed interest in this receptor subtype as a target for the development of novel pharmacological agents to treat insomnia. Focusing primarily on findings in he...
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Serotonin (5-HT) has been shown to participate in prolactin secretion through a complex process resulting in both positive and negative effects. Estrogen has also been recognized as being involved in this serotonergic effect on prolactin release. Therefore, the aim of the present study was to assess whether estradiol modulates serotonergic involvement in prolactin secretion though 5-HT1A and/or...
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This study was designed to examine the effects of intracerebroventricular (ICV) injection of ketanserin(5-HT2a receptor antagonist) and SB242084 (5-HT2c receptor antagonist) on harmaline induced feeding anddrinking response in 24-h food-deprived (FD24) broiler cockerels. At first, guide cannula was surgicallyimplanted in the right lateral ventricle of chickens. In experiment 1, birds were injec...
متن کاملThe physiological role of 5-HT2A receptors in working memory.
Dorsolateral prefrontal cortex has an essential role in the cognitive process of working memory, dysfunction of which is considered to be a core deficit in schizophrenia. Although this cortical region is densely innervated with 5-HT2A receptors to which atypical antipsychotic drugs bind with high affinity, little is known of the influence of this serotonin receptor subtype on prefrontal functio...
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ژورنال
عنوان ژورنال: Cardiovascular Drug Reviews
سال: 1997
ISSN: 0897-5957,1527-3466
DOI: 10.1111/j.1527-3466.1997.tb00326.x